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There is also a third pathway that makes nasal delivery uniquely interesting for certain applications

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The psychology of obesity: an umbrella review and evidence-based map of the psychological correlates of heavier body weight

There are some data to suggest that insulin resistance also occurs in PD [70], however, this is controversial since systemic insulin resistance is not present in de novo, medication-free PD patients [71], and brain insulin resistance is not present in cognitively normal PD cases [72]