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Retatrutide clinical trial data Retatrutide data comes primarily from two sources: a Phase 2 trial published in the New England Journal of Medicine and the Phase 3 TRIUMPH program that began reporting results in mid-2025

Greb D, Hebeisen M, Matter A, Opitz I, Lauk O

Gaps: dosing, delivery, safety, and large RCTs remain

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The exploration of combination strategies, such as GLP-1 RAs with setmelanotide in patients retaining partial MC4R function, may offer additive benefits by targeting both MC4R -dependent and MC4R -independent pathways