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Contrarily, in BPC 157-treated rats, we noted a focal edema of interlobar septe, a diffuse occurrence of 510 necrotic cells/HPF, a focal occurrence of 1116 necrotic cells/HPF, up to one focus of hemorrhage, and up to seven foci of fat necrosis, mostly in the pancreatic tail, while the pancreatic head was not affected with fat necrosis

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RSL3 stimulation elevated C3, IL-1, and TNF- levels in mixed glial cultures, while the ferroptosis inhibitor liproxstatin-1 effectively attenuated RSL3-induced neurotoxicity, supporting a role for ferroptotic stress in promoting neurotoxic glial activation