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After 24 weeks, Mini-Mental State Examination (MMSE) scores didnt significantly improve in the treatment groups compared to the placebo, and the placebo group actually improved significantly more than the B12-only group (Eussen, 2006)

Phase II clinical trials in patients with sarcoidosis-related small fiber neuropathy demonstrated significant increases in corneal nerve fiber density (a reliable surrogate marker for systemic small fiber health) alongside meaningful reductions in neuropathic pain scores

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These findings have positioned FOXO4-DRI as one of the most mechanistically specific senolytic peptides currently available for research purposes, distinguishing it from small-molecule senolytics that operate through broader cellular pathways