Energy stress-mediated AMPK activation and the activation of the Nrf2 antioxidant pathway also play important roles in regulating ferroptosis, through which metformin could alleviate ferroptosis and vascular calcification in high-lipid model mice
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In clinical trials, semaglutide promoted mean weight loss of approximately 16.9% and had beneficial effects on blood pressure, glucose metabolism, inflammatory markers, and lipid profiles [913]
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And in my opinion, its not safe