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This phenomenon, sometimes called tolerance or dose creep, is reported anecdotally with tirzepatide, though the clinical trial data does not show significant tolerance development at fixed doses over 72 weeks
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The prostate tends to enlarge with age and BPH can affect up to 90% of men with advancing age
This may be caused by an inflammatory response in the tissue surrounding the spleen's blood vessels, which can exert pressure on the blood vessels and lead to splenic infarction [116]
Liraglutide is the first drug in this class approved by the FDA and is considered the predecessor to new GLP-1 medications
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