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As with all research compounds, observations may vary depending on experimental conditions, dosage levels, protocol design, and study duration

One study showed that while glucocorticoid treatment suppresses neonatal mice cardiomyocyte proliferation in vitro, the absence of such signaling does not alter the expression of glucocorticoid target genes or maintain cardiomyocyte proliferative potential in neonatal mice

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reported a mean follow-up of 56 months (range, 1300 months) in 26 patients, with frequent recurrences and metastases (37)