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In most, daily doses just below 100mg are where significant effects begin

However, heat stress-induced upregulation of HSF1 and HSP70 silences macroautophagy stimulators such as mitogen-activated protein kinase (MAPK) through mechanisms involving the mammalian target of rapamycin (mTOR) pathway (Sattari et al., 2025)

Confirmatory secondary endpoints included 20%, 25%, and 30% weight loss, with all analyses performed on an intention-to-treat basis and reported with 95% confidence intervals

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Naltrexone reduces ethanol reward signaling without altering the enzymatic metabolism rate