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SOCS2 appears to be the major SOCS-negative regulator of GH signaling as socs2 / mice are 3040% larger than WT littermates while other SOCS knockouts (KOs) do not significantly affect size (124, 125)

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A 2024 in-vitro study showed that heterologous expression of P9 stimulated GLP-1 production in human L-cell lines (World J Microbiol Biotechnol, 2024)

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