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In this review, we not only gathered the most recent discoveries on MTHFR polymorphism and related DNA methylation in various psychiatric disorders, but also highlighted the potential relationships between MTHFR activity and implication of folate-related function in specific mental diseases

Acknowledgements All diagrams are created in BioRender

Maintaining GSH levels could slow age-related neurodegeneration.Acute Brain Injuries:In conditions like stroke or traumatic brain injury, protecting mitochondrial GSH may reduce neuronal damage and improve recovery

The ribosomal subunits of prokaryotes and eukaryotes are quite similar

The absence of the enzyme in these microorganisms is consistent with the lack of GSH [28]