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These varied -synuclein levels and forms in PD patients reported by various study groups might be the result of changes in the secretion, solubility, and aggregation of the protein, thereby affecting its overall turnover

Guasch-Ferre M, Satija A, Blondin SA, Janiszewski M, Emlen E, O'Connor LE, Campbell WW, Hu FB, Willett WC, Stampfer MJ

Lower concentration at any single point

To confirm that CVOTs findings are consistent in more diverse populations reflective of patients in the clinical practice, we may need to look beyond clinical trials to real-world evidence studies