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Higher doses produce greater improvements in glycemic control , larger reductions in hemoglobin A1c, and more substantial decreases in fasting glucose levels

The mechanism appears to operate through multiple pathways: reduced fat mass decreases estrogen production from adipose tissue, lower insulin levels suppress excessive ovarian androgen secretion, and improved endothelial function enhances ovarian blood flow

Also using a toner first helps with absorption, which is fast anyways like you can use it if you only have 1 minute to get out the door in the morning

The half-life of approximately 12 hours with subcutaneous administration allows for flexible protocol design

& Lundberg, G