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Why NSAIDs May Worsen Chronic Pain Over Time When gut integrity is compromised and nutrient absorption declines, inflammatory signaling becomes harder to regulate

Praharaj PP, Singh A, Patra S, Bhutia SK

518 This reflects age-dependent decrease in myelin, linked to a decrease in the number of oligodendrocytes and their precursors

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In this context, it would be important to investigate in future studies whether chronic EtOH fed WT and KO mice differ in the gastric metabolism of ethanol