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ISF Promotes GLP-1 Secretion and Improves Glucose Tolerance in HFD-Fed Obese Mice Exhibiting Hyperglycemia We examined the effects of ISF on GLP-1 secretion and glucose tolerance in high-fat diet (HFD)-fed obese and diabetic mice

The study protocol was reviewed and approved by the Local Ethics Committee of Ivano-Frankivsk National Medical University (protocol No

Although previous ex vivo studies employing NCI-H716 cells (a human L cell line) [35] or human ileal and colonic tissues [14] were indicative of a direct effect of metformin in stimulating GLP-1 release, clinical evidence suggests that the augmentation of postprandial GLP-1 secretion by metformin is largely indirect