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Description

The brown pigments stained positive for Fontana-Masson staining and negative for Berlin blue staining, which were indicative of melanin pigmentation

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Research shows this small molecule is an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy regulation and fat metabolism

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Conversely, in cellular contexts dependent upon Parkin-mediated mitophagy for survival, interference with this pathway via MST1-p53 axis activation or FFAR2/PPAR- signaling blockade enhances cellular susceptibility to ferroptosis upon Erastin treatment

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Single App knock-in mouse models of Alzheimers disease

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