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High levels of IL-17 receptors and IL-17 positive T-cells have been identified in the synovial fluid of these patients

the dose was then increased to 5 mg for the remaining 8 weeks

Bloodbrain barrier and BCB are guarding systems of the brain formed mainly by endothelial cells, which separate the central nervous system (CNS) from the general circulatory system of the body, protecting the brain from toxic metabolites and pathogens (Zenaro et al., 2017)

Oxidative stress can disrupt these tolerance mechanisms by inducing apoptosis of regulatory T cells (Tregs), which are critical for maintaining immune homeostasis and preventing autoimmunity [141]

found a lower percentage of apoptosis in lymphocytes from patients with Graves disease compared to healthy subjects, despite finding greater genomic instability in these cells.23 Similarly, Klatka et al