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In the second embodiment, the present invention is related to a process for producing semapeptide, the process comprising the steps of: a) culturing a host cell comprising a nucleotide sequence encoding of Formula (II) under suitable conditions for expression, Insoluble tag Fusion tag Semapeptide (Nucleotide Sequence) Formula (II) wherein, insoluble tag is a nucleotide sequence of Alanine -Valine

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