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There is also a separate safety question, distinct from efficacy: retatrutide raises resting heart rate by 5 to 10 beats per minute, which has not yet been characterised in patients who already have heart failure or irregular heartbeats

Sync steps, exercises, weight, and food from Apple Health automatically

In early phase 2a trials, it effectively improved glycemic control, increased post-meal insulin levels, and facilitated weight loss in participants with obesity and patients with T2DM [83]

Avoid large, high-fat meals and alcohol to reduce the likelihood of significant nausea

head-to-head comparative data are not yet available, and speculative comparisons should be interpreted cautiously