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Although vitamin E exerts its antioxidant effect by preventing the oxidation of unsaturated fatty acids into hydroperoxides, exogenous antioxidants form the second line of defense against free radical damage in the body

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IGF-1 LR3 acts at the opposite end of that axis, as an exogenous receptor agonist applied directly at the endpoint, bypassing the feedback control entirely

Improved Muscle Function and Endurance: Supports muscle health and recovery, particularly important as we age or engage in strenuous physical activities

The table lists berberine supplementation at 2-4% weight loss in some studies, labels the evidence quality as limited RCT data, and describes the proposed mechanism as AMPK activation with mixed results