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So, at least in these doses (more than twice the Institute of Medicine recommendation), there appears to be no additional health benefit

Propionic acid stimulates superoxide generation in human neutrophils

35 , e3158 (2019)

[20] Yet another meta-analysis and qualitative review of clinical studies concludes: Ibuprofen is as or more efficacious than acetaminophen for the treatment of pain and fever in adult and pediatric populations and is equally safe