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This action is working in conjunction with the brain as it influences appetite suppression and energy expenditure by interacting with neuronal circuits that regulate hunger and fullness (Zhang et al

In a randomized, single-blind, 24-week study, participants assigned to dual therapy of 2 mg weekly of the GLP-1 receptor agonist exenatide (Bydureon, AstraZeneca) and 10 mg daily of the SGLT2 inhibitor dapagliflozin (Farxiga, AstraZeneca) lost more weight than those taking either agent alone or those receiving dapagliflozin and metformin extended-release (Xigduo XL, AstraZeneca) or phentermine/topiramate extended-release (Qsymia, Vivus)

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[6,7] Because GLP-1s like Ozempic can make you feel fuller faster and eat less overall, its common to experience some digestive changes

Baggio L, Kieffer TJ, and Drucker DJ