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For instance, appetite suppression or improved insulin sensitivity may persist for hours to days, depending on the specific GLP-1 used and individual metabolic factors

Understanding these contributing factors is essential for appropriate clinical assessment and management

The prolonged receptor occupancy achieved by synthetic analogues ensures sustained pharmacological activity, translating to once-daily or once-weekly dosing regimens that improve treatment adherence and patient outcomes

The most commonly reported side effects are mild and include a temporary increase in hunger (related to its ghrelin receptor activity), mild water retention during the initial weeks, tingling or numbness in the extremities, and occasional headache

Epidemiology 29, 4149