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Among these, the proactive approach is characterized by the early administration of desmopressin to control renal free water clearance at the beginning of treatment, specifically in patients at increased risk of developing ODS

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After reconstitution with sterile water or an approved solvent, the solution must be refrigerated at 28C and used within 1430 days as specified in the research protocol or product documentation

About 15% of patients are non-responders, often due to concurrent nutrient deficiencies (like magnesium or folate) that require additional supplementation for full therapeutic effect