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It binds and unbinds in a constant exchange, so some free copper ions escape and irritate local nerve endings while activating mast cells (immune cells that release histamine and trigger inflammation)
But proper dosage, placement, and timing make a huge difference
It is produced naturally by the body and is found in every cell, where it acts as a powerful antioxidant and detoxifier
The appearance of a pronucleus was used as the indicator of successful activation, suggesting that the oocyte had completed meiotic maturation and was capable of initiating embryonic development independently of fertilization
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