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Study Design and Population OASIS 4 was a randomized, double-blind, placebo-controlled trial conducted across 22 sites in Canada, Germany, Poland, and the United States

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After successful model establishment, the experimental group received 4 weeks of gavage administration with the test samples, during which the animals had free access to food

The initial and maintenance dosing of metformin should be conservative in patients with advanced age, due to the potential for decreased renal function in this population