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Skotland TK, Sandvig A, Llorente

Chronic glucocorticoid use, certain medications with myopathy as a rare side effect (such as statins or fluoroquinolones), and systemic illnesses can promote muscle catabolism

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NICE Clinical Knowledge Summary (CKS) on constipation in adults recommends a stepwise approach, typically starting with bulk-forming laxatives (such as ispaghula husk) for many adults, with osmotic laxatives (such as macrogol) added or substituted if response is inadequate or stools remain hard