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This is also why a secretagogue approach is framed as "axis-friendly": because endogenous somatostatin is still in the loop, negative feedback is preserved, which in principle restrains the supraphysiologic IGF-1 spikes seen with exogenous GH

Telomerase the ribonucleoprotein enzyme complex that maintains telomere length is silenced in most human somatic cells, contributing to the progressive telomere shortening that drives replicative senescence

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DOI: 10.2174/1381612822666160914182822