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These changes may cause disordered sympathetic and parasympathetic activity (158, 360) as well as PEM and cognitive dysfunction (29)

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Pharmacology [edit] Metabolism and half-life [edit] Tesofensine has a long half-life of about 9 days (220 h) [4] "and is mainly metabolized by cytochrome P4503A4 (CYP3A4) to its desalkyl metabolite M1" NS2360

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