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This improvement happens as your body builds tolerance to the medication and adapts to how semaglutide affects your stomach and intestines

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Weeks 1-4: 0.25mg weekly subcutaneous injection Weeks 5-8: 0.5mg weekly subcutaneous injection Weeks 9-12: 1.0mg weekly subcutaneous injection Weeks 13+: 1.0mg maintenance or increase to 1.7-2.4mg based on response The starting dose of 0.25mg per week produces minimal appetite suppression but allows gastrointestinal adaptation

Laski, "The BTM domain, primarily found in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes of Drosophila", Proc

Am J Physiol Endocrinol Metab 273: E981-988, 1997