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The clinical efficacy of ALC and NAC has been evaluated in several trials [167, 172, 176, 199, 210, 237], the preliminary encouraging data and physiopathological frameworks support the need to study these compounds in this context and clarify their role [23, 24, 28, 199]

Chronic caffeine use causes the brain to grow more adenosine receptors to compensate

Atractylenolide I can enhance Lactobacillus and Bacteroides , reduces the levels of Escherichia and Candidatus , and by suppressing the TLR4/MyD88/NF-B pathway to reduce IL-1 and LPS levels ( Actinobacteria growth, elevates Bacteroidetes levels (Ren et al., 2021)

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