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It was identified before GLP-1 and was actually the first incretin hormone described in the literature

PF-04236921, a monoclonal IL-6 antibody failed to meet its primary efficacy endpoint (SRI-4) a phase II trial that enrolled 183 patients assigned to receive subcutaneous 10 mg, 50 mg or 200 mg drug or placebo (103)

The dosing interval should be extended to allow more time between doses

activation of a GABA-A receptor thus leads to efflux of Cl ions from the cell (that is, a depolarizing current)