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A network meta-analysis of 76 randomized controlled trials covering 39,246 patients found that tirzepatide produced the largest HbA1c reduction at negative 2.10% versus placebo, followed by semaglutide

(4) patients not diagnosed with MASLD

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As circadian rhythms are prevalent within physiological processes within the gut [8], there is the potential for some time-of-day variability in the absorption of orally administered drugs and in the speed of gastric emptying following a meal [8, 9]

Managing side effects : Common adverse effects of Wegovy include: Nausea, vomiting, and diarrhoea (usually transient and improving over time) Constipation Abdominal discomfort Fatigue Some of these symptoms overlap with hypothyroidism symptoms, which can make it challenging to distinguish between inadequate thyroid replacement and medication side effects