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A major characteristic of SARS-CoV-2 infection is oxidative stress, which leads to inflammation and vascular dysfunction

doi: 10.1038/s41416-020-01156-1 55 SchiliroCFiresteinBL

GRh3 prevents NRF2 from entering the nucleus, which in turn inhibits SLC7A11.This causes a depletion of GSH, an accumulation of iron, and elevated levels of ROS and MDA, ultimately triggering ferroptosis in colorectal cancer cells (74)

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At the onset of RBC storage the released microvesicles differ in composition from those released from Ca 2+ -loaded RBC