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Doubleblind, randomized clinical trial assessing the efficacy and safety of early initiation of sitagliptin during metformin uptitration in the treatment of patients with type 2 diabetes: The CompoSIT-M study

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Additional consideration should be given to vitamin D (most people are deficient regardless of weight), omega-3 fatty acids for inflammation support, magnesium for muscle function and sleep quality, and electrolytes to replace what is lost through the increased water excretion that accompanies early weight loss