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Patients should be counselled about common gastrointestinal symptoms, advised to start with the lowest dose (2.5 mg weekly), and informed that side effects typically improve over 4-8 weeks as tolerance develops

In 2005, more than 15 years later, the first GLP-1 drug for diabetes was approved

GLP-1 receptor stimulation triggers pathways through: Phosphoinositol-3 kinase/AKT serine/threonine kinase (PI3K/Akt) Mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) [6] These pathways control cell growth and proliferation, and DPP-IV plays a vital role in thyroid malignancy progression [3]

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SIRT6 maintains telomere integrity and DNA repair