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4.7 Clinical evidence of Hydroxytyrosol Current clinical evidence for HTY remains limited and is largely based on short-term intervention studies assessing biochemical and oxidative stressrelated biomarkers rather than definitive clinical endpoints and most available trials involve healthy individuals or populations at increased cardiometabolic risk, with intervention durations ranging from 3 to 26 weeks and daily HTY intakes typically between ~ 5 and 15 mg, either as purified supplements or through high-phenolic extra virgin olive oil [102]