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Glutathione is the primary carrier in Phase II

Embo J 40:e106700 Gullett JM, Tweedell RE, Kanneganti TD (2022) Its all in the PAN: crosstalk, plasticity, redundancies, switches, and interconnectedness encompassed by PANoptosis underlying the totality of cell death-associated biological effects

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Animal studies have revealed that mild to moderate acoustic overexposure, even when causing only a temporary threshold shift (TTS), can immediately and permanently induce cochlear synaptopathycharacterized by the loss of synaptic connections between cochlear hair cells and auditory nerve fibers, without any loss of the hair cells themselves 16,17,18