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These effects were independent of acute sickness and linked to impaired cognition and motivation, particularly continuous attention and curiosity, through prolonged central amygdala activation

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Tie et al, 2009), yet the significance of CBP/p300 (and H3K27ac) to NRF2 activity has not been explored for the broader NRF2 transcriptome

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However, assessment of long-term, hard clinical kidney endpoints has been limited by the three- to fivefold higher risk of hyperkalaemia with spironolactone use [66]