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In de eerste weken kun je tijdelijk last hebben van: Misselijkheid Buikklachten Verstopping of diarree Meestal wordt dit snel minder

The rationale involves maintaining optimal healing capacity before injuries occur rather than responding after damage happens

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Initial dosing starts at 2.5 mg weekly to improve tolerability and is titrated every 4 weeks in 2.5 mg increments to a maximum of 15 mg, providing six dosing options: 2.5 mg 5 mg 7.5 mg 10 mg 12.5 mg 15 mg The initial low dose is not intended as the full therapeutic dose, but to reduce gastrointestinal side effects while patients adapt