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platensis has been used by humans for centuries as evidenced by reports from Mexico and Central Africa.2 Currently, it is widely used as a nutraceutical namely for the prevention of diabetes, although numerous other biological effects have been ascribed to this alga.2 Among many potentially-bioactive substances, PCB and chlorophylls, represent compounds of particular interest due to their structural resemblance to bilirubin, a potent antioxidant, atheroprotective, and anti-proliferative agent.24 In fact, the anticancer action of bilirubin has been attributed to its effects on mitochondria28 as well as intracellular signalization.29 In addition, bilirubin was found to be a widespread inhibitor of protein phosphorylation,30 which might account for these biological properties
2012;11:CD000254
Further research is required to optimize the inducing dose and to discover models that can cover the full scope of AD pathogenesis
Furthermore, MOTS-c has been shown to reduce signaling from Myostatin (a negative regulator of muscle growth) and inhibit pathways that cause muscle wasting (sarcopenia)
