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The C-terminal tail of c-MET binds to numerous Src homology 2 domain containing effectors, such as PI3-K, the non-receptor kinase Src, the growth factor receptor bound protein 2 (GRB2) and SH2 domain-containing transforming protein (SHC) adaptors SHP2 (also known as PTPN11

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But its power to slow digestion often comes with an uncomfortable side effect: relentless nausea

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So, while DPP-IVs may offer a better gastrointestinal (GI) adverse event profile than GLP-1RAs, they are generally less effective at reducing HbA 1C and have a lower potential for weight loss