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For pernicious anaemia or malabsorption, intramuscular hydroxocobalamin is the NHS standard treatment, with an initial loading regimen followed by maintenance injections every 2-3 months

The secreted Fr-DEGs identified were ceruloplasmin (CP), high mobility group box 1 (HMGB1) and transferrin (TF)

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Long-term use of NSAIDs can lead to impaired glomerular filtration, renal tubular necrosis, and ultimately chronic renal failure by disrupting prostaglandin synthesis, which can impair renal blood flow (Weir 2002)