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Supporting this notion, MS interactomic analyses of GLP-1R co-immunoprecipitates in INS-1 832/3 SNAP/FLAG-hGLP-1R cells after a 5-minute stimulation with the endogenous agonist GLP-1, as well as with the exendin-4-based biased GLP-1RAs exendin-F1 and exendin-D3, previously shown to trigger differing degrees of GLP-1R internalisation 18,19 , resulted in marked differences in the propensity of the receptor to associate with VAPB (Supplementary Fig

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