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The effectiveness of pulsed electric field extraction depends on various factors, including the electric field strength, treatment time, and the specific properties of the plant tissue, such as cell size, shape, and membrane composition ( Another constraint is related to the physical and chemical characteristics of the extraction matrix

Its launch marked Novo Nordisk's full entry into the obesity pharmacotherapy market a market that soon exploded in size as these new GLP-1-based medications showed unprecedented efficacy (15% or more weight loss in many patients)

Of significant concern is whether or not impurities that make the peptide appear more foreign (by changing the tolerogenic epitope) might impact the immunogenicity of the drug product