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Zamil DH, Ameri M, Fu S, Abughosh FM, Katta R

This is particularly relevant for oral administration, which is subject to intrinsic factor saturation and receptor limitations in the ileum ( Moreover, our results highlight the essential role of vitamin B12 in homocysteine metabolism, as supplementation was associated with a significant reduction in serum homocysteine levelsan important biomarker associated with cardiovascular and neurodegenerative diseases

However, reduced dietary intake due to appetite suppression may decrease B12 consumption, particularly in patients with additional risk factors such as restricted diets or concurrent medications affecting absorption

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