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Tesamorelin has the strongest fat-loss evidence in the category: two Phase 3 RCTs, 816 patients, and 15% visceral fat reduction by CT scan over 26 weeks

In a surgically induced-OA model in rats, liraglutide also attenuated rat cartilage degeneration through suppressing the release of inflammatory mediators and protected chondrocytes against endoplasmic reticulum (ER) stress and apoptosis induced by interleukin-1 (IL-1) or triglycerides [46]

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